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Win-K Cell

As leader in cancer treatment, Wincell has develop cancer treatments under the name Win-K cell , an innovative treatment to defeat cancer. Win-K cell is suitable for both the initial stage and invasion stage. With the concept of Anti Cancer Immune Therapy by which the white blood cell (lymphocyte) is make stronger to treat cancer yet friendly to the patient’s body.

Win-K cell is first progress from liver cancer patients and since has been widely accepted as international standard. In order to support this new paradigm of treatment, National Science and Technology Development Agency and Thailand leading medical school has selected human resources and standardize production with cutting edge technology in order to provide a one stop services of cancer treatments.

Characteristics

Win-K Cell consists of 2 essential components :

  1. Cytotoxic T Lymphocytes (CTL)
  2. Cytokine induced Killer Cells (CIK) since the two cells have different properties in destroying tumor cells.

1) Qualification of Cytotoxic T Lymphocytes (CTL):

CTL specifically target tumor cells (MHC restricted pattern) by attaching its Receptor to Tumor Antigen of the tumor cells, and releases Cytotoxic, a chemical which has a property to destroy tumor cells.

2) Qualification of Cytokine induced Killer Cells (CIK):

The Mechanism that activates the destruction of tumor cells by CIK derives from CIK recognizes the tension surrounding of tumor cells (Tumor Microenvironment) which is unsuitable for the normal cells to live, thus, CIK cells can be activated by many types of tumor cells and are not subject to any specific type of tumor cells. It does not activated specifically to MHC (non-majorhistocompatibility complex-restricted). Once detected, CIK will release an enzyme to destroy the membrane of tumor cells.

CIK Cells is a cell from white blood cell (lymphocyte)- mononuclear type – which is drawn from peripheral vessel or spleen of the animal being tested and cultivated outside the body by giving interferon-g, CD3-antibody and interleukin-2.

Cultivated CIK cells, which express marker of natural killer cells (NK), together with T cells expressing receptor natural killer group 2D (NKG2D). The mechanism that activates the destruction of tumor cells is done by CIK cells detecting the tension surrounding of tumor cells (tumor microenvironment) which is unsuitable for the normal cells to live.

CIK cells are not restricted to a specific major histocompatibility complex (MHC), meaning , Win-K cells can be activated by many types of tumor cells and are not subject to any specific type of tumor cells. Since CIK cells does not being activated by a specific MHC (non-majorhistocompatibility complex-restricted). CIK cells and tumor cells will contact and CIK cells will produce perforin to be released to destroy cell membrane of tumor cells without the depending on eFas in stimulating the perforin production. Additionally, it is observed that CIK cells can produce cytokines ie. IFN-g, RANTES, MIP1a and MIP1b. Cytokines will work with IFN-g in destroying tumor cells in the same process as T helper1 and Tcell.



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